Harnessing scientific developments in practice

Harnessing Scientific Literature Reports for Pharmacovigilance

OBJECTIVES We seek to develop a prototype software analytical tool to augment FDA regulatory reviewers' capacity to harness scientific literature reports in PubMed/MEDLINE for pharmacovigilance and adverse drug event (ADE) safety signal detection. We also aim to gather feedback through usability testing to assess design, performance, and user satisfaction with the tool. METHODS A prototype, o...

Harnessing immunosurveillance: current developments and future directions in cancer immunotherapy

Despite improved methods of cancer detection and disease management over the last few decades, cancer remains a major public health problem in many societies. Conventional therapies, such as chemotherapy, radiation, and surgery, are not usually sufficient to prevent disease recurrence. Therefore, efforts have been focused on developing novel therapies to manage metastatic disease and to prolong...

Scientific developments in indoor tanning and melanoma.

CI: confidence interval OR: odds ratio UV: ultraviolet I n this month’s Journal of the American Academy of Dermatology online, Lim et al summarize a large body of evidence that relates to the regulation of indoor ultraviolet (UV) tanning. From a public health perspective, the most important aspect of this issue is the association of indoor tanning with melanoma, the leading cause of death among...

Developments in the scientific understanding of osteoporosis

During the past 10 years we have experienced very significant developments in our understanding of bone biology, and this has improved our abilities to both diagnose and treat patients with osteoporosis. This review covers some of the significant discoveries in bone biology that have led to a better understanding of osteoporosis, including a few of the discoveries that have been translated into...

Scientific Method in Practice